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Acid-Base Disorders and Their Treatment by F. John Gennari, Horacio J. Adrogue, John H. Galla, Nicolaos

By F. John Gennari, Horacio J. Adrogue, John H. Galla, Nicolaos Maddias

With special contributions and examine from specialists within the body structure of ordinary acid-base homeostasis and the administration of acid-base issues, this reference provides an abundance of knowledge on acid-base body structure, issues of acid-base equilibrium, and the administration and therapy of those problems in medical perform. a different and well timed resource, this consultant offers a good number of tables, references, and figures to demonstrate the connection among the underlying body structure and analysis of acid-base issues.

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Biophysical Chemistry. New York: Academic Press, 1966. Singer RB, Hastings AB. Improved clinical method for estimation of disturbances of acid–base balance in human blood. Medicine 1948; 27:223–242. Rossi-Bernardi L, Roughton FJW. The specific influence of carbon dioxide and carbamate compounds on the buffer power and Bohr effects in human haemoglobin solutions. J Physiol 1967; 189:1–29. German B, Wyman J. The titration curves of oxygenated and reduced hemoglobin. J Biol Chem 1937; 117:533–550. Phillips R, Eisenberg P, George P, Rutman RJ.

In the closed system, the total quantity of buffer (acid plus base components) remains constant. In the open system, PCO2 (and thus [dissolved CO2]) is maintained at a fixed level by continuous equilibration of the liquid phase with a gas reservoir at a constant PCO2 of 40 mmHg. which a solution containing HCOÀ 3 at a concentration of 24 mEq=L is equilibrated with a PCO2 of 40 mmHg at 37 C. 40 ([Hþ] ¼ 40 nEq=L). If 10 mmol of HCl is added to a liter of this solution, the 10 mEq of Hþ dissociated from this strong acid will immediately combine with HCOÀ 3 , forming H2CO3 and reducing [HCOÀ 3 ] from 24 to 14 mEq=L.

N Engl J Med 1982; 306:864–866. 0 32. Gennari FJ. Is pK ok? New Engl J Med 1982; 307:683. 33. Austin WH, Ferrante V, Anderson C. Evaluation of whole blood pK in the acutely ill patient. J Lab Clin Med 1968; 72:129–135. 34. DeRaedt M, Vandenbergh E, Van de Woestijne KP. Direct and indirect determination of partial pressure of CO2 in the arterial blood of patients with respiratory insufficiency. Clin Sci 1968; 35:347–352. 35. Van Slyke DD, Hastings AB, Hiller A, Sendroy J. Studies of gas and electrolyte equilibria in blood.

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